Regenerate damaged tissues, joints, ligaments, and tendons with ozone.

Prolozone is a non-surgical ligament and joint reconstruction. It is an oxygen-ozone injection technique that combines the concepts from neural therapy, prolotherapy, and ozone therapy. It comes from the Latin word “proli” (proliferate) which means to regenerate or rebuild, and the word ozone. Prolozone is a permanent treatment for many kinds of chronic pain.
How Prolozone Works
Developed by Dr. Frank Shallenberger, prolozone involves injecting combinations of procaine, anti-inflammatory medications, homeopathics, vitamins, minerals, proliferatives, and ozone/oxygen gas into degenerated or injured joints, and into areas of pain. This increases blood supply and the flow of healing nutrients to that specific area. The circulation of critical elements in the bloodstream is essential to the natural regeneration and healing process of the body giving tissues the energy they need to repair.


Ozone is the most highly active form of oxgyen in the universe. Prolozone utilizes this powerful oxidizing agent to stimulate growth factor production of collagen and cartilage which restores joint integrity.
Since prolozone involves the injection of gas which expands into surrounding tissue, very large and difficult to reach areas can be treated with only one injection because ozone is able to disperse and benefit anything nearby.
Around since the 1950s in Europe, prolozone is becoming increasingly popular in the United States as an alternative to surgery that is minimally invasive and more accessible. Many chronic pain sufferer become permanently pain free with increased long-term function because prolozone actually corrects the pathology of the disorder.
Conditions That Respond
The main criteria for choosing prolozone is pain. If it hurts, it should be tried since it works on most pain problems. For situations that involve instability in addition to pain, prolozone should be combined with prolotherapy. The following conditions have been found to be especially responsive.
Regenerative Injection Therapies Comparison
Below is a chart to get a better understanding of the similarities and differences between regenerative injection therapies, including cortisone steroid shots. The best way to get the appropriate treatment for your individual situation is to book an appointment with Dr. Riddle at Core Wellness to get evaluated.